It’s inflammation-causing molecules C3 and C4 in joint fluid that attacks the cartilage causing pain. Advanced Knee Discovery has a natural ingredient that curbs these inflammatory molecules

Extensive research at Stanford University School of Medicine discovered that knee pain was “not a matter of simple wear and tear” like the vast majority of doctors believed. The scientific evidence they developed points in the direction of inflammation, specifically molecules C3 and C4.

Doctors Were Surprised by This Remarkable Study Result…

Scientists at Stanford now believe that by targeting these two inflammatory molecules, relief could be found because research indicates that inflammation was significantly reduced. The immune system mistakenly releases millions of these two inflammatory molecules in the synovial fluid around the knee.


They inflame and weaken knee cartilage, causing severe pain. Scientists at Stanford believe that this condition is the underlying cause of joint pain and cartilage damage.

This pioneering approach is changing the way many think about this health concern.


Even many doctors still don’t know these facts. Advanced Knee Discovery brings you a unique formula based on this discovery and its unique ingredients. Consider…

Appropriate product claims will be made to comply with regulatory requirements in various countries and individual markets. This private information is solely to help highlight scientific efficacy. A partial listing of the science-backed nutraceuticals in this formulation is included below.

The Japanese Orthopedic Association finds pain improvements with olive leaf extract

Using their measurement for knee functionality, they tested olive leaf extract on 25 people with knee osteoarthritis. 36% improved in going up and down stairs; pain walking on a flat space improved 51% compared to the placebo; discomfort while sleeping improved 60%. (3)

The most powerful antioxidant found--olive leaf extract--15X stronger than green tea

The unique olive leaf extract hydroxytyrosol has an oxygen radical absorbance capacity of 68,576. This helps stop cell-damaging free radicals. That’s 3 times higher than CoC10 and 15 times more than green tea. Free radicals help create and spread pain-causing inflammation. (4)

Polygonum cuspidatum helped reduce inflammation 66% in a randomized, double-blind study

Indices of inflammation—TNF-alpha and IL-6 were reduced up to 66% more than the placebo by polygonum cuspidatum—trans resveratrol. This study consisted on 20 male professional basketball players with persistently high levels of inflammation due to intense activity. (5)

Mayo Clinic study on vitamin D3 and pain revealed 93% in discomfort were deficient in D3

This Mayo Clinic study on the role of D3 and pain offers important new information. 93% of those suffering from pain were deficient in vitamin D3. Pain increased as vitamin D levels went lower. (6) Worse, a vitamin D deficiency makes people more sensitive to pain. (7)

Harvard Health reveals a B-12 deficiency can cause “pins and needles and severe joint pain.”

Harvard’s Massachusetts General Hospital reports on a B-12 deficiency that caused trouble walking and joint pain in an article published in The New England Journal of Medicine.  (8)

A B-6 deficiency mimicked painful cartilage osteoarthritis, as reported by the National Institutes of Health. (9)

Stanford University's pioneering work reveals a new way forward

It was considered medical wisdom in its day—but modern science is now believed to say that it could have been wrong. Knee pain from wear and tear seemed to make sense. Now scientists at Stanford think it is an inflammatory problem and by “targeting the inflammatory process” relief could be indeed be found. (10)

Sources and Notes:

(3) Takeda R, et al. Double-blind placebo-controlled trial of hydroxytryrosol of Olea europaea on pain in gonarthrosis. Phytomedicine. 2013. 20:861-864.

(4)  Raederstorff D, et al. Antioxidant activity of olive polyphenols in humans: a review.

Int J Vitam Nutr Res. 2009 May;79(3):152-65. doi: 10.1024/0300-9831.79.3.152.

(5) Zahedi HS, et al. Effects of Polygonum Cuspidatum Containing Resveratrol on Inflammation in Male Professional Basketball Players. Int J Prev Med. 2013 Apr; 4(Suppl 1): S1–S4.